Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF.

Vineet Agrawal Jonathan A Kropski Jason J GokeyElizabeth KobeckMatthew B MurphyKatherine T Murray Niki L FortuneChristy S MooreDavid F MeoliKen Monahan Yan Ru SuThomas BlackwellDeepak K GuptaMegha H TalatiSanthi GladsonErica J Carrier James D West Anna R Hemnes

Published in: Circulation research (2023)

We report a novel model for the study of PH and right heart remodeling in HFpEF, and we identify myeloid cell-derived IL-1β as an important contributor to PH in HFpEF.

Keyphrases

pulmonary hypertension
bone marrow
dendritic cells
acute myeloid leukemia
heart failure
atrial fibrillation
pulmonary arterial hypertension
coronary artery