Kidney Disease Progression in Membranous Nephropathy among Black Participants with High-Risk APOL1 Genotype.
Dhruti P ChenCandace D HendersonJaeline AnguianoClaudia P AielloMary M CollieVanessa MorenoYichun HuSusan L HoganRonald J Falknull nullPublished in: Clinical journal of the American Society of Nephrology : CJASN (2023)
The prevalence of high-risk APOL1 variant among Black membranous nephropathy participants is comparable with the general Black population (10%-15%), yet the high-risk genotype was associated with worse eGFR decline and faster time to kidney failure compared with low-risk genotype and participants that were not Black.