Login / Signup

Investigation of MicroRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis.

Melissa E BakerSeungmee LeeMichael ClintonMatthias HacklCatarina CastanheiraMandy J PeffersSarah Elizabeth Taylor
Published in: International journal of molecular sciences (2022)
Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. MicroRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondrocytes in monolayer culture. This is the first equine study to evaluate the role of miR-92a in osteoarthritic chondrocytes in vitro.
Keyphrases
  • cell proliferation
  • long non coding rna
  • rheumatoid arthritis
  • knee osteoarthritis
  • long noncoding rna
  • minimally invasive
  • transcription factor
  • early onset
  • stem cells
  • single cell
  • extracellular matrix
  • drug induced