Peripherally delivered hepatopreferential insulin analog insulin-406 mimics the hypoglycaemia-sparing effect of portal vein human insulin infusion in dogs.

Justin M GregoryGuillaume KraftMelanie F ScottDoss W NealBen FarmerMarta S SmithJon R HastingsPeter MadsenThomas B KjeldsenSusanne HostrupChristian L BrandChristian FledeliusErica NishimuraAlan D Cherrington

Published in: Diabetes, obesity & metabolism (2019)

Peripheral infusion of hepatopreferential insulin can achieve a metabolic profile that closely mimics portal insulin delivery, which reduces the risk of hypoglycaemia compared with peripheral insulin infusion.

Keyphrases

type diabetes
glycemic control
low dose
endothelial cells
insulin resistance
metabolic syndrome
skeletal muscle
adipose tissue
weight loss
minimally invasive