Connexin 43 plays an important role in the transformation of cholangiocytes with Clonochis sinensis excretory-secretory protein and N-nitrosodimethylamine.
Eun-Min KimYoung Mee BaeMin-Ho ChoiSung-Tae HongPublished in: PLoS neglected tropical diseases (2019)
These results suggest that Cx43 is an important factor in CHCA induced by C. sinensis ESP and NDMA and further investigations targeting this pathway may allow prevention of this deadly disease.