First Case of HIV Seroconversion With Integrase Resistance Mutations on Long-Acting Cabotegravir for Prevention in Routine Care.
Catherine A KossMonica GandhiElias K HalvasHideaki OkochiCarolyn ChuDavid V GliddenLisa Georgetti GomezAmy L HeapsAmy A ConroyMichael TranCory ShetlerDianna HoethKaren KunczeAlexander LouieHana Rivera GarzaErick Wafula MugomaKerri J PenroseBhavna H ChohanJames O AyiekoAnthony MillsRupa R PatelJohn W MellorsUrvi M ParikhPublished in: Open forum infectious diseases (2024)
In this first case of HIV infection on CAB-LA with INSTI resistance in routine care, cabotegravir resistance was detected only with a sensitive research assay. Accelerated pathways to minimize time between HIV testing and CAB-LA initiation are needed to optimize acute HIV detection and mitigate resistance risk. Sustained product access regardless of insurance is imperative to reduce HIV infections on CAB-LA.
Keyphrases
- hiv testing
- men who have sex with men
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- hiv aids
- hepatitis c virus
- healthcare
- palliative care
- quality improvement
- clinical practice
- high throughput
- affordable care act
- liver failure
- south africa
- pain management
- drug induced
- intensive care unit
- acute respiratory distress syndrome