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First Case of HIV Seroconversion With Integrase Resistance Mutations on Long-Acting Cabotegravir for Prevention in Routine Care.

Catherine A KossMonica GandhiElias K HalvasHideaki OkochiCarolyn ChuDavid V GliddenLisa Georgetti GomezAmy L HeapsAmy A ConroyMichael TranCory ShetlerDianna HoethKaren KunczeAlexander LouieHana Rivera GarzaErick Wafula MugomaKerri J PenroseBhavna H ChohanJames O AyiekoAnthony MillsRupa R PatelJohn W MellorsUrvi M Parikh
Published in: Open forum infectious diseases (2024)
In this first case of HIV infection on CAB-LA with INSTI resistance in routine care, cabotegravir resistance was detected only with a sensitive research assay. Accelerated pathways to minimize time between HIV testing and CAB-LA initiation are needed to optimize acute HIV detection and mitigate resistance risk. Sustained product access regardless of insurance is imperative to reduce HIV infections on CAB-LA.
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