Detection of 8-oxoguanine and apurinic/apyrimidinic sites using a fluorophore-labeled probe with cell-penetrating ability.
Dong Min KangJong-Il ShinJi Beom KimKyungho LeeJi Hyung ChungHye-Won YangKil-Nam KimYe Sun HanPublished in: BMC molecular and cell biology (2019)
These results revealed that the TAT-S3 probe successfully detected the presence of 8-oxoG and AP sites in damaged cells. The TAT-S3 probe may have applications for the detection of diseases caused by reactive oxygen species.
Keyphrases
- living cells
- reactive oxygen species
- quantum dots
- single cell
- fluorescent probe
- loop mediated isothermal amplification
- induced apoptosis
- real time pcr
- label free
- transcription factor
- cell cycle arrest
- cell therapy
- endoplasmic reticulum stress
- mesenchymal stem cells
- computed tomography
- sensitive detection
- oxidative stress
- bone marrow
- pi k akt
- positron emission tomography