Negative impact of chronic graft-versus-host disease and glucocorticoid on the recovery of physical function after allogeneic hematopoietic stem cell transplantation.
Jin HayakawaDaijiro MiyamuraShun-Ichi KimuraAyumi GomyoMasaharu TamakiYu AkahoshiNaonori HaradaTomotaka UgaiMachiko KusudaKazuaki KamedaHidenori WadaYuko IshiharaKoji KawamuraKana SakamotoMiki SatoKiriko Terasako-SaitoMisato KikuchiHideki NakasoneShinichi KakoYoshinobu KandaPublished in: Bone marrow transplantation (2018)
Quality of life of patients who undergo allogeneic hematopoietic stem cell transplantation (HSCT) temporally deteriorates and recovers over several years. We retrospectively evaluate the impact of chronic graft-versus-host disease (GVHD) and glucocorticoid on physical recovery. We included 162 patients who underwent their first allogeneic HSCT between October 2010 and December 2015 in a single hospital. All patients are planned to undergo physical function tests before and 1, 3, 12 months after allogeneic HSCT. Scores of knee extension strength and distance covered in the 6-min walk test (6MWT) recovered at the 12-month assessment. Both chronic GVHD and high dose glucocorticoid were associated with delayed recovery of body mass index (BMI), hand grip strength, knee extension strength, and duration of standing on one foot. Lung GVHD and high dose glucocorticoid had negative impact on the distance covered in the 6MWT. A multivariate analysis revealed that chronic GVHD and glucocorticoid was an independent risk factor for decreased BMI and delayed recovery of muscle strength, respectively. Our results suggest that high-risk patients who have chronic GVHD or who receive glucocorticoid therapy may require reduced dose of glucocorticoid and long-term physical support to recover physical function after transplantation.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- end stage renal disease
- body mass index
- high dose
- newly diagnosed
- acute myeloid leukemia
- ejection fraction
- acute lymphoblastic leukemia
- chronic kidney disease
- physical activity
- stem cell transplantation
- peritoneal dialysis
- prognostic factors
- mental health
- stem cells
- healthcare
- low dose
- total knee arthroplasty
- hematopoietic stem cell
- weight gain
- cell therapy
- smoking cessation
- adverse drug
- anterior cruciate ligament reconstruction