Impact of Varicocele on Testicular Oxidative Stress and Sperm Parameters in Experimental Animals: A Systematic Review and Meta-Analysis.

Giorgio Ivan Russo Ramadan Saleh Federica Finocchi Almas Ramadhani Juma Damayanthi Durairajanayagam Oguzhan Kahraman Emrullah Sogutdelen Ioannis Sokolakis Ranjit B Vishwakarma Fahmi Bahar Ahmed M Harraz Parviz K Kavoussi Widi Atmoko Eric Chung Naveen Kumar Wael Zohdy Amarnath Rambhatla Mohamed Arafa Nguyen Ho Vinh Phuoc Gianmaria Salvio Aldo Eugenio Calogero Tuncay Toprak Germar-Michael Pinggera Rossella Cannarella Giovanni M Colpi Forum Taha Abo-Almagd Abdel-Meguid Hamoda Rupin Shah Ashok Agarwal

Published in: The world journal of men's health (2024)

This SRMA indicates a significant increase in levels of testicular MDA and SDF and a reduction of sperm quality in experimental animals with varicocele. These findings support the potential role of testicular OS in the development of varicocele-induced testicular damage.

Keyphrases

germ cell
oxidative stress
diabetic rats
dna damage
high glucose
ischemia reperfusion injury
endothelial cells
signaling pathway
risk assessment
cell proliferation
quality improvement
endoplasmic reticulum stress
stress induced