Influence of cell type and cell culture media on the propagation of foot-and-mouth disease virus with regard to vaccine quality.
Veronika DillBernd HoffmannAline ZimmerMartin BeerMichael EschbaumerPublished in: Virology journal (2018)
The selective pressure of the available surface receptors in different cell culture systems may be responsible for alterations in the capsid coding sequence of culture-grown virus. Important vaccine potency characteristics such as viral titer and the neutralization profile were unaffected, but the 146S particle yield differed for one of the tested serotypes.
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