CD38 is methylated in prostate cancer and regulates extracellular NAD.

Jack MottahedehMichael C HaffnerTristan R GroganTakao HashimotoPreston D CrowellHimisha BeltranAndrea SbonerRohan BarejaDavid EsopiWilliam B IsaacsSrinivasan YegnasubramanianMatthew B RettigDavid A ElashoffElizabeth A PlatzAngelo M De MarzoMichael A TeitellAndrew S Goldstein

Published in: Cancer & metabolism (2018)

CD38 protein expression in prostate cancer is associated with risk of recurrence. Methylation results suggest that CD38 is epigenetically regulated in localized and metastatic prostate cancer tissues. Our study provides support for CD38 as a regulator of extracellular, but not intracellular, NAD+ in epithelial cells. These findings suggest that repression of CD38 by methylation may serve to increase the availability of extracellular NAD+ in prostate cancer tissues.

Keyphrases

prostate cancer
radical prostatectomy
gene expression
small cell lung cancer
transcription factor
dna methylation
genome wide