P-FAB: A Fiber-Optic Biosensor Device for Rapid Detection of COVID-19.
Divagar MuruganHimanshu BhatiaV V R SaiJitendra SatijaPublished in: Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology (2020)
Rapid and low-cost diagnosis of COVID-19 is essential to identify the infected subjects, particularly the asymptomatic cases, primarily to arrest the spread of the disease through local transmission. Antibody-based chromatographic serological tests, as an alternative to RT-PCR, offer only limited help due to high false positives. We propose to exploit our field-deployable/portable plasmonic fiber-optic absorbance biosensor (P-FAB) platform for one-step, wash-free detection of SARS-CoV-2 virus particles directly in saliva sample with minimal sample pre-processing.
Keyphrases
- sars cov
- low cost
- label free
- loop mediated isothermal amplification
- sensitive detection
- coronavirus disease
- respiratory syndrome coronavirus
- optical coherence tomography
- gold nanoparticles
- quantum dots
- real time pcr
- optic nerve
- high throughput
- cell cycle
- mass spectrometry
- simultaneous determination
- cell proliferation
- single cell