Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases.

Antero SalminenKai KaarnirantaAnu Kauppinen

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

Given that cellular senescence, inflammaging, and counteracting immune suppression increase with aging, this might explain why excessive insulin/IGF-1 signaling promotes the aging process.

Keyphrases

type diabetes
glycemic control
binding protein
endothelial cells
growth hormone
weight gain
adipose tissue
oxidative stress
metabolic syndrome