Isorhamnetin ameliorates cisplatin-induced acute kidney injury in mice by activating SLPI-mediated anti-inflammatory effect in macrophage.

Jia JianLi Yu-QingHan Rang-YueZhong XiaXie Ke-HuanYan YingWang LiTan Rui-Zhi

Published in: Immunopharmacology and immunotoxicology (2024)

Isorhamnetin inhibits macrophage inflammation and protects kidney in AKI may be related to downregulating Mincle/Syk/NF-κB-maintained macrophage phenotype by activating SLPI.

Keyphrases

signaling pathway
adipose tissue
oxidative stress
anti inflammatory
acute kidney injury
pi k akt
lps induced
tyrosine kinase
high fat diet induced
mouse model
inflammatory response
insulin resistance