Modelling porcine NAFLD by deletion of leptin and defining the role of AMPK in hepatic fibrosis.

Tan TanZhiyuan SongWenya LiRunming WangMingli ZhuZuoxiang LiangYilina BaiQi WangHanyu WuXiaoxiang HuYiming Xing

Published in: Cell & bioscience (2023)

The Leptin-deficient pigs presents an ideal model to illustrate the full spectrum of human NAFLD. The activity of AMPK signaling pathway suggests a potential target to develop new strategy for the diagnosis and treatment of NAFLD.

Keyphrases

signaling pathway
endothelial cells
skeletal muscle
pi k akt
protein kinase
induced apoptosis
wild type