Bile Acid Regulates Mononuclear Phagocytes and T Helper 17 Cells to Control Candida albicans in the Intestine.
Abhishek DattaJuan F Hernandez-FrancoSungtae ParkMatthew R OlsonHarm HogenEschShankar ThangamaniPublished in: Journal of fungi (Basel, Switzerland) (2022)
Invasive Candida albicans ( CA ) infections often arise from the intestine and cause life-threatening infections in immunocompromised individuals. The role of gut commensal microbiota, metabolites, and host factors in the regulation of CA colonization in the intestine is poorly understood. Previous findings from our lab indicate that taurocholic acid ( TCA ), a major bile acid present in the intestine, promotes CA colonization and dissemination. Here, we report that oral administration of TCA to CA-infected mice significantly decreased the number of mononuclear phagocytes and CD4+ IL17A+ T helper 17 cells that play a critical role in controlling CA in the intestine. Collectively, our results indicate that TCA modulates mucosal innate and adaptive immune responses to promote CA colonization in the intestine.
Keyphrases
- candida albicans
- immune response
- induced apoptosis
- biofilm formation
- protein kinase
- dendritic cells
- cell cycle arrest
- regulatory t cells
- ms ms
- skeletal muscle
- metabolic syndrome
- oxidative stress
- signaling pathway
- cell proliferation
- toll like receptor
- cystic fibrosis
- pseudomonas aeruginosa
- inflammatory response
- insulin resistance
- respiratory failure
- high fat diet induced