Ratio of low molecular weight serum adiponectin to the total adiponectin value is associated with type 2 diabetes through its relation to increasing insulin resistance.
Minoru IwataKazuo HaraYutaka KamuraHisae HonokiShiho FujisakaManabu IshikiIsao UsuiKunimasa YagiYasuo FukushimaAtsuko TakanoHiromi KatoShihou MurakamiKiyohiro HiguchiChikaaki KobashiKazuhito FukudaYukiko KoshimizuKazuyuki TobePublished in: PloS one (2018)
The current investigation demonstrated that, unlike the reduction in the levels of all the adiponectin isoforms and the HMW/TA ratio, an increased LMW/TA ratio was associated with T2D through its relation to insulin resistance.