Multiphotocatalyst Cascades: From Furans to Fused Butyrolactones and Substituted Cyclopentanones.
Lamprini-Panagiota ApostolinaArtemis BosveliAntonia ProfyllidouTamsyn MontagnonVasileios TsopanakisMaria KaloumenouDimitris KalaitzakisGeorgios VassilikogiannakisPublished in: Organic letters (2022)
High value oxygenated polycycles have been rapidly and efficiently accessed from simple precursors in one pot processes. The reported methodology relies on a new and mild method for butenolide synthesis mediated by thiols. The initial photooxygenation and butenolide synthesis have been merged with subsequent photoredox reactions to achieve rare dual-photocatalyst cascades affording various fused butyrolactones. Ground state Lewis acid activity for methylene blue has been unveiled and then exploited in the synthesis of substituted cyclopentanones.