Reducing effect of the novel positive allosteric modulator of the GABAB receptor, COR659, on binge-like alcohol drinking in male mice and rats.

Irene LorraiChase ShankulaJorge Marquez GaytanTomoya KawamuraPaola MaccioniClaudia MugnainiFederico CorelliGian Luigi GessaPietro Paolo SannaGiancarlo Colombo

Published in: Psychopharmacology (2021)

The present data demonstrate the ability of COR659 to suppress binge-like drinking in rodents and strengthen the hypothesis that GABAB PAMs may represent a potentially effective pharmacotherapy for alcohol misuse.

Keyphrases

alcohol consumption
small molecule
chronic pain
electronic health record
big data
smoking cessation
machine learning
binding protein
deep learning