Design and quality control of large-scale two-sample Mendelian randomization studies.
Philip C HaycockMaria Carolina BorgesKimberley BurrowsRozenn N LemaitreSean HarrisonStephen BurgessXuling ChangJason WestraNikhil K KhankariKostas K TsilidisTom GauntGibran HemaniJie ZhengTherese TruongTracy A O'MaraAmanda B SpurdleMatthew H LawSusan L SlagerBrenda M BirmannFatemeh Saberi HosnijehDaniela MariosaChristopher I AmosRayjean J HungQuan LongMarc J GunterGeorge Davey SmithCaroline ReltonRichard M Martinnull nullPublished in: International journal of epidemiology (2023)
In this large MR collaboration, 11.6% of included studies were affected by a substantial metadata error or analytical issue. By increasing the integrity of collated summary data prior to their analysis, our protocol can be used to increase the reliability of downstream MR analyses. Our pipeline is available to other researchers via the CheckSumStats package (https://github.com/MRCIEU/CheckSumStats).