Accuracy of a no-biopsy approach for the diagnosis of coeliac disease across different adult cohorts.
Hugo A PennySuneil A RajuMichelle S LauLauren Js MarksElisabeth Mr BaggusJulio C BaiGabrio BassottiHetty J BontkesAntonio CarroccioMihai DanciuMohammad H DerakhshanArzu EnsariAzita GanjiPeter H R GreenMatt W JohnsonSauid IshaqBenjamin LebwohlAdam LeveneRoxana MaximHamid Mohaghegh ShalmaniMohammad Rostami-NejadDavid RowlandsIrene A SpiridonAmitabh SrivastavaUmberto VoltaVincenzo VillanacciGraeme WildSimon S CrossKamran RostamiDavid S SandersPublished in: Gut (2020)
Our results show that IgA tTG titres of ≥10×ULN have a strong predictive value at identifying adults with intestinal changes diagnostic of CD. This study supports the use of a no-biopsy approach for the diagnosis of adult CD.