The Analysis of the Anti-Tumor Mechanism of Ursolic Acid Using Connectively Map Approach in Breast Cancer Cells Line MCF-7.

Weiqiang GuoBin XuXiaoxiao WangBo ZhengJiahui DuSong-Bai Liu

Published in: Cancer management and research (2020)

Our data indicated that the anti-tumor effects of UA are due to the inhibited RAF/ERK pathway and IKK/NF-κB pathway. It could also be explained by the reduced phosphorylation of PLK1 in MCF-7 cells. This study provides a new insight for deep understanding of the new anti-cancer mechanisms of UA in MCF-7 breast cancer cells.

Keyphrases

breast cancer cells
signaling pathway
induced apoptosis
pi k akt
cell cycle arrest
oxidative stress
cell proliferation
electronic health record
big data
endoplasmic reticulum stress
protein kinase
immune response
deep learning
data analysis