Genomic disparity impacts variant classification of cancer susceptibility genes in Turkish breast cancer patients.
Nihat Buğra AğaoğluBusra UnalConnor P HayesMcKenzie WalkerOzden Hatirnaz NgLevent DoganayNisan D CanHuma Q RanaArezou A GhazaniPublished in: Cancer medicine (2024)
To our knowledge, this is the first study of population genetic effects in breast cancer subtypes in Turkish women. Our findings underscore the need for a large genomic database representing Turkish population-specific variants. It further highlights the significance of the ancestry-appropriate population database for accurate variant assessment in clinical settings.
Keyphrases
- copy number
- genome wide
- healthcare
- machine learning
- high resolution
- emergency department
- squamous cell carcinoma
- polycystic ovary syndrome
- papillary thyroid
- adverse drug
- adipose tissue
- gene expression
- dna methylation
- metabolic syndrome
- young adults
- squamous cell
- lymph node metastasis
- genome wide association study
- genome wide association