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Surfactant therapy for COVID-19 related ARDS: a retrospective case-control pilot study.

Simone PivaRobert M DiBlasiApril E SleeAlan H JobeAldo M RoccaroMatteo FilippiniNicola LatronicoMichele BertoniJohn C MarshallMichael A Portman
Published in: Respiratory research (2021)
Surfactant delivery through bronchoscopy at a dose of 720 mg in 150 ml normal saline is feasible and safe for COVID-19 ARDS patients and health care providers during the pandemic. Surfactant administration did not cause acute decompensation, may reduce mortality and mechanical ventilation duration in COVID-19 ARDS patients. This study supports the future performance of randomized clinical trials evaluating the efficacy of meticulous sub-bronchial lavage with surfactant as treatment for patients with COVID-19 ARDS.
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