Single-cell analysis reveals the implication of vascular endothelial cell-intrinsic ANGPT2 in human intracranial aneurysm.

Guo YuJia LiHongfei ZhangHuaxing ZiMingjian LiuQingzhu AnTianming QiuPeiliang LiJianping SongPeixi LiuKai QuanSichen LiYingjun LiuWei ZhuJiu-Lin Du

Published in: Cardiovascular research (2024)

By performing a landscape view of the single-cell transcriptomes of IA and the control artery, we contribute to a deeper understanding of the cellular composition and the molecular changes of ECs in IA. The implication of angiogenic regulator ANGPT2 in IA formation and progression, provides a novel potential therapeutical target for IA interventions.

Keyphrases

single cell
endothelial cells
rna seq
high throughput
coronary artery
physical activity
transcription factor
risk assessment
abdominal aortic aneurysm