Prefrontal cortex brain damage and glycemic control in patients with type 2 diabetes.
Sarah E ChoiBhaswati RoyMatthew FreebyRashmi MullurMary A WooRajesh KumarPublished in: Journal of diabetes (2020)
T2DM patients showed PFC brain tissue damage, which is associated with cognitive deficits and poor glycemic control. Further research is needed to identify causal relationships between HbA1c, cognition, and brain changes in T2DM and to evaluate the impact of interventions to prevent brain tissue injury or neuroregeneration in this high-risk patient population, to eventually preserve or enhance cognition and improve glucose outcomes.
Keyphrases
- glycemic control
- white matter
- type diabetes
- blood glucose
- resting state
- weight loss
- functional connectivity
- prefrontal cortex
- end stage renal disease
- cerebral ischemia
- insulin resistance
- newly diagnosed
- multiple sclerosis
- ejection fraction
- chronic kidney disease
- mild cognitive impairment
- prognostic factors
- skeletal muscle