Central nervous system complications associated with immune checkpoint inhibitors.
Alberto VogrigSergio Muñiz-CastrilloBastien JoubertGeraldine PicardVeronique RogemondCécile MarchalAnne Marie ChiappaEve ChansonFrançois SkowronAmelie LeblancFrançois DucrayJerome HonnoratPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
Three main clinical phenotypes characterise CNS complications of ICIs, each with distinct immunological background, disease course and response to treatment. Other clinical manifestations (including parkinsonism and steroid-responsive confusion) are also possible. Underlying cancers, antibody prevalence and outcome appear different from those of patients with PN-ICI.