GLT-1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice.
Xin-Hao JiaoJie WanWei-Feng WuLin-Hui MaChen ChenWei DongYi-Qi LiuChun-Hui JinAo SunYue ZhouZi-Yi LiQiang LiuYu-Qing WuCheng-Hua ZhouPublished in: CNS neuroscience & therapeutics (2024)
These findings suggest that the adult mice with type 2 diabetes are at an increased risk of developing POCD, perhaps due to the downregulation of GLT-1 in hippocampal astrocytes, which enhances increased glutamatergic neuron excitability induced by A/S and leads to oxidative stress reaction, and neuronal apoptosis.
Keyphrases
- oxidative stress
- type diabetes
- high fat diet induced
- cerebral ischemia
- cell proliferation
- signaling pathway
- endoplasmic reticulum stress
- insulin resistance
- dna damage
- patients undergoing
- wild type
- diabetic rats
- induced apoptosis
- skeletal muscle
- childhood cancer
- glycemic control
- transcranial direct current stimulation
- blood brain barrier
- brain injury
- weight loss