Conditioned media from endothelial progenitor cells cultured in simulated microgravity promote angiogenesis and bone fracture healing.

Lingchi KongYan WangHaixing WangQi PanRongtai ZuoShanshan BaiXiaoting ZhangWayne Yukwai LeeQinglin KangGang Li

Published in: Stem cell research & therapy (2021)

These findings provided insight into the use of MG bioreactor to enhance the angiogenic properties of EPCs' paracrine signals via HIF-1α/eNOS/NO axis, and the administration of MG-CM favored bone fracture repair.

Keyphrases

endothelial cells
bone mineral density
soft tissue
vascular endothelial growth factor
bone loss
bone regeneration
hip fracture
postmenopausal women
body composition
pi k akt