Association between triglycerides, known risk SNVs and conserved rare variation in SLC25A40 in a multi-ancestry cohort.
Elisabeth A RosenthalDavid R CrosslinAdam S GordonDavid S CarrellIan B StanawayEric B LarsonJane GraftonWei-Qi WeiJoshua C DennyQi-Ping FengAmy S ShahAmy C SturmMarylyn D RitchieJennifer A PachecoHakon HakonarsonLaura J Rasmussen-TorvikJohn J ConnollyXiao FanMaya SafarovaIftikhar J KulloGail P JarvikPublished in: BMC medical genomics (2021)
Analysis using data from electronic health records presents challenges that need to be overcome. Although large amounts of genotype data is becoming increasingly accessible, usable phenotype data can be challenging to obtain. We were able to replicate known, strong associations, but were unable to replicate moderate associations due to the limited sample size and missing drug information.