Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.

Neil C DalvieJoseph R BradyLaura E CrowellMary Kate TraceyAndrew M BiedermannKawaljit KaurJohn M HickeyD Lee KristensenAlexandra D BonnymanSergio A Rodriguez-AponteCharles A WhittakerMarina BokCelina VegaTarit K MukhopadhyaySangeeta B JoshiDavid B VolkinViviana ParreñoKerry R LoveJohn Christopher Love

Published in: Microbial cell factories (2021)

This study demonstrates that molecular engineering of subunit antigens using advanced genomic methods can facilitate their manufacturing in continuous production. Such capabilities have potential to lower the cost and volumetric requirements in manufacturing vaccines based on recombinant protein subunits.

Keyphrases

dendritic cells
single molecule
protein kinase
gene expression
immune response
binding protein
climate change