A Multipathogen Bile Sample-based PCR Assay Can Guide Empirical Antimicrobial Strategies in Cholestatic Liver Diseases.
Michael JahnMustafa K ÖzçürümezSebastian DolffHana RohnDominik HeiderAlexander DechênePeter LemmerPeter M RathAntonios KatsounasPublished in: Journal of clinical and translational hepatology (2022)
mRT-PCR in conjunction with CMCs for bile analysis increased diagnostic sensitivity and may benefit infection management in patients with cholestatic diseases. Implementation of mRT-PCR in a bile sample-based diagnostic routine can support more rapid and targeted use of antimicrobial agents in cCLD-patients undergoing ERCP and reduce the rate/length of unnecessary administration of broad-spectrum antibiotics.