WDR5 inhibition halts metastasis dissemination by repressing the mesenchymal phenotype of breast cancer cells.

Simona PunziChiara BalestrieriCarolina D'AlesioDaniela BossiGaetano Ivan DellinoElena GattiGiancarlo PruneriCarmen CriscitielloGiulia LovatiMarine MeliksetyanAlessandro CarugoGiuseppe CuriglianoGioacchino NatoliPier Giuseppe PelicciLuisa Lanfrancone

Published in: Breast cancer research : BCR (2019)

We suggest that WDR5 inhibition could be a promising pharmacologic approach to reduce cell migration, revert EMT, and block metastasis formation in BC, thus overcoming resistance to standard treatments.

Keyphrases

cell migration
breast cancer cells
epithelial mesenchymal transition
stem cells
bone marrow
signaling pathway