Baseline Clinical and Blood Biomarker in Patients With Preataxic and Early-Stage Disease Spinocerebellar Ataxia 1 and 3.

Sophie Tezenas Du MontcelEmilien PetitTitilayo OlubajoJennifer FaberPauline Lallemant-DudekKhalaf BusharaSusan PerlmanSub H SubramonyDavid MorganBrianna JackmanHenry Lauris PaulsonGülin ÖzThomas KlockgetherAlexandra DürrTetsuo Ashizawanull null

Published in: Neurology (2023)

READISCA showed the feasibility of harmonized data acquisition in a multi-national network. NfL alterations, early sensory ataxia and corticospinal signs were quantifiable between preataxic participants and controls. Patients with ataxia differed in many parameters from controls and mutation carriers without ataxia, with a graded increase of abnormal measures from control to preataxic to ataxic cohorts.

Keyphrases

early onset
early stage
electronic health record
big data
quality improvement
machine learning
transcranial magnetic stimulation
lymph node
sentinel lymph node
radiation therapy
deep learning