Naturally occurring caffeic acid phenethyl ester from chestnut honey-based propolis and virtual screening towards DYRK1A.
Idris ArslanPublished in: Natural product research (2024)
Neurodegenerative diseases (NDDs) are disorders with dysfunction and ongoing loss of neurons, glial cells and the neural networks in the brain and spinal cord. DYRK1A protein was reported to modulate to the cytoskeletal fraction in human and mouse brain, and the remaining protein is located in the cytosolic and nuclear fractions. Caffeic acid phenethyl ester (CAPE) is a natural derivative of caffeic acid and found in propolis, a bee product. In this study, we focused on isolation and characterisation of CAPE from chestnut honey-based propolis by HPLC-MS/MS technique and virtual screening of CAPE towards DYRK1A by molecular docking methods. Results revealed that CAPE might be a beneficial option to treat Alzheimer disease (AD) by suppressing DYRK1A protein.
Keyphrases
- south africa
- molecular docking
- ms ms
- spinal cord
- neural network
- protein protein
- endothelial cells
- neuropathic pain
- amino acid
- induced apoptosis
- spinal cord injury
- molecular dynamics simulations
- simultaneous determination
- white matter
- mass spectrometry
- cell proliferation
- liquid chromatography tandem mass spectrometry
- multiple sclerosis
- signaling pathway