Obacunone can inhibit blood coagulation and improve inflammatory response by regulating PROC and F2R. It regulates MIF, S100A9, G6PD and IL-10 to play a role in immune response. It regulates CTSG, CASP1, MAPK1, C5AR1 and CASP3 to protect sepsis-damaged organs. By regulating CXCR2, it can reduce the excessive migration of neutrophils to the site of inflammation, alleviate tissue damage. By regulating NAMPT, it improves cellular energy status, reduces oxidative stress, and protects cells from damage.
Keyphrases
- oxidative stress
- inflammatory response
- immune response
- septic shock
- acute kidney injury
- intensive care unit
- diabetic rats
- ischemia reperfusion injury
- dna damage
- induced apoptosis
- lipopolysaccharide induced
- toll like receptor
- lps induced
- weight gain
- dendritic cells
- human health
- heat shock
- risk assessment
- cell proliferation
- cell migration