A new experimental evidence-weighted signaling pathway resource in FlyBase.
Helen AttrillGiulia AntonazzoJoshua L GoodmanJim ThurmondVictor B StreletsNicholas H Brownnull nullPublished in: Development (Cambridge, England) (2024)
Research in model organisms is central to the characterization of signaling pathways in multicellular organisms. Here, we present the systematic curation of 17 Drosophila signaling pathways using the Gene Ontology framework to establish a comprehensive and dynamic resource that has been incorporated into FlyBase, providing visualization and data integration tools to aid research projects. By restricting to experimental evidence reported in the research literature and quantifying the amount of such evidence for each gene in a pathway, we captured the landscape of empirical knowledge of signaling pathways in Drosophila.
Keyphrases
- signaling pathway
- pi k akt
- epithelial mesenchymal transition
- induced apoptosis
- genome wide
- copy number
- systematic review
- healthcare
- magnetic resonance
- gram negative
- electronic health record
- gene expression
- magnetic resonance imaging
- computed tomography
- dna methylation
- data analysis
- network analysis
- genome wide analysis
- electron microscopy