Harnessing stress granule formation by small molecules to inhibit the cellular replication of SARS-CoV-2.

Wan Gi ByunJihye LeeSeungtaek KimJong Beom Park

Published in: Chemical communications (Cambridge, England) (2021)

We identified small-molecule enhancers of cellular stress granules by observing molecular crowding of proteins and RNAs in a time-dependent manner. Hit molecules sensitized the IRF3-mediated antiviral mechanism in the presence of poly(I:C) and inhibited the replication of SARS-CoV-2 by inducing stress granule formation. Thus, modulating multimolecular crowding can be a promising strategy against SARS-CoV-2.

Keyphrases

sars cov
small molecule
respiratory syndrome coronavirus
stress induced
signaling pathway
big data
dendritic cells
heat stress
immune response
deep learning