Elevated levels of prostaglandin E2 in the tears of patients with severe allergic conjunctivitis and primary cultured conjunctival cells are suppressed by ketotifen and dexamethasone.
Ryutaro YamanishiNaoko OkadaEisuke ShimizuHiroshi FujishimaPublished in: BMJ open ophthalmology (2021)
PGE2 may participate in the pathogenesis of severe ocular allergic disease, and both ketotifen fumarate and steroid reduce the production of PGE2.