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Elevated levels of prostaglandin E2 in the tears of patients with severe allergic conjunctivitis and primary cultured conjunctival cells are suppressed by ketotifen and dexamethasone.

Ryutaro YamanishiNaoko OkadaEisuke ShimizuHiroshi Fujishima
Published in: BMJ open ophthalmology (2021)
PGE2 may participate in the pathogenesis of severe ocular allergic disease, and both ketotifen fumarate and steroid reduce the production of PGE2.
Keyphrases
  • induced apoptosis
  • early onset
  • cell cycle arrest
  • allergic rhinitis
  • low dose
  • endoplasmic reticulum stress
  • cell death
  • cell proliferation
  • atopic dermatitis
  • optical coherence tomography
  • optic nerve