Cumulative corticosteroid-sparing effect of anti-interleukin-5/5Ra in eosinophilic asthma.
Johannes A KroesSybrand W J ZielhuisKim De JongSimone HashimotoJacob K SontSander W ZielhuisEric N Van RoonElisabeth H BelAnneke Ten Brinkenull nullPublished in: The European respiratory journal (2022)
This real-world study showed that anti-IL-5/5Ra therapy leads to a significant reduction in cumulative OCS exposure over a 2-year period. Patients with lower and shorter OCS exposure were more likely to completely eliminate OCS. Since cumulative exposure increased progressively prior to anti-IL-5/5Ra initiation, our data suggest that early intervention leads to a better long-term prognosis in patients with severe eosinophilic asthma.