Comprehensive multiplexed autoantibody profiling of patients with advanced urothelial cancer.

Praful RaviDory FreemanJonathan ThomasArvind RaviCharlene MantiaBradley A McGregorJacob E BerchuckIlana EpsteinPetra BuddeBehnaz Ahangarian AbhariElena RupieperJana GajewskiAnn-Sophie SchubertAnnika L KilianManuel BräutigamHans-Dieter ZuchtGuru P Sonpavde

Published in: Journal for immunotherapy of cancer (2024)

This is the first report of comprehensive AAb profiling of patients with mUC and identified key AAbs that were elevated in patients with mUC versus HCs as well as AAbs associated with therapeutic response to ICI. These findings are hypothesis generating and further mechanistic studies evaluating humoral immunity in UC are required.

Keyphrases

single cell
papillary thyroid
immune response
squamous cell
squamous cell carcinoma
case control
urinary tract
childhood cancer