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Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma.

Yimin TaoWei LuJinli GaoShuangshuang YangChaoyi RuanYingying HouJing LuJunjiu XuJianjian ZhangStephanie Pasas-FarmerQiuping QinLikun Gong
Published in: Molecules (Basel, Switzerland) (2024)
The assay met both methodological and sample-related ADA tolerance requirements, and was applicable to a nonclinical study in cynomolgus monkeys.
Keyphrases
  • high throughput
  • tyrosine kinase
  • magnetic resonance
  • computed tomography
  • diffusion weighted imaging