Mesenchymal stem cells decrease lung inflammation during sepsis, acting through inhibition of the MAPK pathway.

Leonardo PedrazzaMonica Cubillos-RojasFernanda Cristina de MesquitaCarolina LuftAline Andrea CunhaJose Luis RosaJarbas Rodrigues de Oliveira

Published in: Stem cell research & therapy (2017)

This study demonstrated that MSCs are able to inhibit the MAPK pathway activation, modulating the inflammatory response during sepsis. This understanding that MSCs can remodel the response of host cells and improve the course of sepsis is essential for developing new treatments for this pathology.

Keyphrases

mesenchymal stem cells
signaling pathway
septic shock
inflammatory response
oxidative stress
acute kidney injury
umbilical cord
intensive care unit
induced apoptosis
pi k akt
bone marrow
cell cycle arrest
lps induced
lipopolysaccharide induced
endoplasmic reticulum stress