Asymmetric hydrogenation of TIPS-protected oximes with chiral boranes.
Kuai YuXiangqing FengHaifeng DuPublished in: Organic & biomolecular chemistry (2022)
An enantioselective metal-free hydrogenation of TIPS-protected oximes has been successfully realized for the first time by using chiral borane catalysts derived from chiral dienes and Piers' borane. A variety of hydroxylamine derivatives were afforded in 84-99% yields with 33-68% ees.