HbA1c and brain health across the entire glycaemic spectrum.
Victoria GarfieldAliki-Eleni FarmakiSophie V EastwoodRohini MathurChristopher T RentschKrishnan BhaskaranLiam SmeethNish ChaturvediPublished in: Diabetes, obesity & metabolism (2021)
Both prediabetes and known diabetes are harmful in terms of VD, cognitive decline and AD risks, as well as lower HV. Associations appeared to be somewhat driven by antihypertensive medication, which implies that certain cardiovascular drugs may ameliorate some of the excess risk. Low-normal HbA1c levels, however, are associated with more favourable brain health outcomes and warrant more in-depth investigation.
Keyphrases
- cognitive decline
- type diabetes
- mild cognitive impairment
- resting state
- white matter
- healthcare
- public health
- functional connectivity
- blood pressure
- human health
- mental health
- cerebral ischemia
- emergency department
- glycemic control
- metabolic syndrome
- risk assessment
- adipose tissue
- drug induced
- social media
- adverse drug