Exploring ITM2A as a new potential target for brain delivery.

Céline CegarraC ChavesC DéonT M DoB DumasA FrenzelP KuhnV RoudieresJ C GuillemotD Lesuisse

Published in: Fluids and barriers of the CNS (2022)

The present work describes our efforts to explore the potential of ITM2A as a target mediating transcytosis through the BBB, and highlights the multiple challenges linked to the identification of new brain delivery targets. Our data provide evidence that antibodies against ITM2A are internalized in ITM2A-overexpressing HEK293 cells, and that ITM2A is expressed in brain microvessels, but further investigations will be needed to demonstrate that ITM2A is a potential target for brain delivery.

Keyphrases

resting state
white matter
functional connectivity
blood brain barrier
cerebral ischemia
induced apoptosis
machine learning
oxidative stress
big data
climate change
signaling pathway