Hepatotoxicities Induced by Neoadjuvant Chemotherapy in Colorectal Cancer Liver Metastases: Distinguishing the True From the False.
Marie DesjardinBenjamin BonhommeBrigitte Le BailSerge EvrardVéronique BrousteGregoire DesolneuxMarianne FonckYves BécouarnDominique BéchadePublished in: Clinical Medicine Insights. Oncology (2019)
There is a probable association between non-alcoholic steatohepatitis (NASH) and irinotecan. Oxaliplatin seems to lead to higher vascular lesions. Except in the presence of pre-existent comorbidities, liver toxicities should not restrain the use of pre-operative chemotherapy prior to parenchymal-sparing surgery.
Keyphrases
- neoadjuvant chemotherapy
- liver metastases
- locally advanced
- minimally invasive
- rectal cancer
- coronary artery bypass
- squamous cell carcinoma
- sentinel lymph node
- radiation therapy
- robot assisted
- lymph node
- liver injury
- surgical site infection
- drug induced
- liver fibrosis
- percutaneous coronary intervention
- atrial fibrillation
- early stage