A Near-Infrared Fluorescent Probe for Recognition of Hypochlorite Anions Based on Dicyanoisophorone Skeleton.
Chang-Xiang LiuShu-Yuan XiaoXiu-Lin GongXi ZhuYa-Wen WangYu PengPublished in: Molecules (Basel, Switzerland) (2023)
A novel near-infrared (NIR) fluorescent probe ( SWJT-9 ) was designed and synthesized for the detection of hypochlorite anion (ClO - ) using a diaminomaleonitrile group as the recognition site. SWJT-9 had large Stokes shift (237 nm) and showed an excellent NIR fluorescence response to ClO - with the color change under the visible light. It showed a low detection limit (24.7 nM), high selectivity, and rapid detection (within 2 min) for ClO - . The new detection mechanism of SWJT-9 on ClO - was confirmed by 1 H NMR, MS spectrum, and the density functional theory (DFT) calculations. In addition, the probe was successfully used to detect ClO - in HeLa cells.
Keyphrases
- fluorescent probe
- living cells
- density functional theory
- loop mediated isothermal amplification
- photodynamic therapy
- label free
- real time pcr
- molecular dynamics
- magnetic resonance
- multiple sclerosis
- cell cycle arrest
- mass spectrometry
- visible light
- induced apoptosis
- high resolution
- oxidative stress
- quantum dots
- molecular dynamics simulations
- drug release
- molecular docking
- cell death
- crystal structure
- light emitting