Morphology-based selection from available euploid blastocysts induces male-skewed sex proportion in the offspring.
Marcos Iuri Roos KulmannCarolina Lumertz MartelloLuiza Mezzomo DonattiAdriana Bos-MikichNilo FrantzPublished in: Journal of assisted reproduction and genetics (2021)
Blastocyst features associated with a skewed sex proportion towards XY embryos, such as biopsy on day 5 and top quality TE, are also parameters used for selecting euploid embryos for SET. Therefore, our data suggest that morphology-based embryo selection represents a strong factor responsible for a skewed male sex proportion at birth in PGT-A cycles.