Clinical Predictors of Cisplatin Chemoradiation-Induced Ototoxicity in HPV-Positive Oropharyngeal Squamous Cell Carcinoma: A Case-Control Study.
John Jw LeeSalahaldin AlamlehLuna Jia ZhanKatrina HuenikenMary B MahlerAstrid Billfalk-KellyJoel DaviesM Catherine BrownAnna SpreaficoShao Hui HuangAndrew HopeWei XuDavid P GoldsteinGeoffrey LiuPublished in: Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale (2024)
Clinical predictors of ototoxicity in HPV-positive OPSCC patients treated with cisplatin-based chemoradiation include the use of a high-dose cisplatin regimen, higher cochlear radiation doses, a history of smoking, and older age. With the rising incidence of this malignancy in Western countries and overall improved survivorship, our research motivates future studies into risk stratification and earlier interventions to mitigate and reduce the risk of ototoxicity.